Nangirin is one of the major flavonoids in grapefruit, and it is responsible for its bitter taste. It occurs naturally in citrus fruits and in human beings; it is normally metabolized to flavanone naringenin. Some people take this component in grape fruit juice so as to enhance their tastes as it is linked to stimulation of taste buds. It also has many effects in the body.
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Naringin protects the cancer patients against toxins which are produced by the chemotherapy drugs. It enhances the healing in chemotherapy processes and is thus recommended for cancer treatment. It also helps in metabolizing lipids in the body as well as any ethanol taken. The negative effects of the ethanol in the body can also be decreased through the use of this flavonoid.
This component has also been known to fight any free radicals and as such reduce the effects of premature ageing. The free radicals break down and deplete the skin of the important collagen and elastin proteins responsible for smooth and supple skin. When taken, the flavonoid restores the skin.
As an antioxidant, it protects the body in many ways. It boosts the body’s immunity and breaks down the toxins which may cause diseases such as cancer and the side effects of radiation and other toxins that enter the body. It also has anti-carcinogenic properties which protect the body from carcinogenic matter. It has anti-apoptopic properties and it is also anti-therogenic. The component is used in treating gastric lesions.
It can also be used to reduce risks of catching diseases such as atherosclerosis and hypercholesterolemia as well as the retinal diseases which are connected to diabetes. It also prevents oxidation of LDL. Despite all these benefits, the component has its own side effects which can be quite severe.
Studies have indicated that the component tends to interfere with enzyme activity in intestines. This may result in interference with breakdown of some drugs causing higher levels of these drugs in the blood and body system. This may have adverse effects on the activity of some drugs like sedatives and medications used in treating hypertension. The component acts as a blocker for calcium and estrogen in some drugs. Some of the drugs that are majorly affected by naringin are those treating allergies; sedatives; AIDS and drugs which reduce cholesterol in the body.
While this property helps in fast metabolism of the drugs relatively fast and thus making it more effective in some cases, it can increase the level of these drugs to toxic levels in the bloodstream. So it is recommended that prior to taking this component in grapefruit juices or any supplements, it is advisable that one consults with the doctor to determine its reaction with the medication.
This property also helps in extending the half-life of some other components in the drugs as well as that in caffeine. This is because its properties are cumulative and may last for longer hours. This way, they can be used with some drugs to increase their activities in the body and cause faster healing. This should however be tried only under the doctor’s recommendation.
